According to Brett McMurphy of ESPN, the BYU Cougars and the South Florida Bulls will announce the signing of a home-and-home series in 2021 and 2022. The schools haven't made the official announcement at this time, so details will still be forthcoming.
The University of South Florida was established in 1956, but didn't start their football program until 1997. They started out as a lower level independent team and then moved up to 1-A (Current FBS) in 2001, again competing as an independent program. In 2003 they joined Conference USA and then the Big East two years later. With the changes of the college football landscape, the Bulls now find themselves in the American Athletic Conference. The Bulls play their home games in Raymond James Stadium, which also houses the Tampa Bay Buccaneers.
USF has competed from the time they joined the FBS level, even making an appearance in the rankings at #2 in October of 2007. The games between the schools will be the first meetings between the programs, but there is a possibility of playing in a bowl game as the Cougars have an agreement with the AAC owned Miami Bowl this year. This type of agreement can be a win-win for the programs as USF needs to play, and host, quality programs and BYU is always looking for ways to invade Florida for recruiting. With Florida being one of the top 3 states for recruiting players, anytime a team can make its presence known, it is a good thing.